Vascular calcifications are the consequence of several pathological conditions such as atherosclerosis, diabetes, hypercholesterolemia and chronic renal insufficiency. They are associated with risks of amputation, ischemic heart disease, stroke and increased mortality. A growing body of evidence indicates that vascular smooth muscle cells (VSMCs) undergo chondrogenic commitment eventually leading to vascular calcification, by mechanisms similar to those governing ossification in the cartilage growth plate. Our knowledge of the formation of cartilage growth plate can therefore help us to understand why and (...) how arteries calcify and, consequently, develop new therapeutic strategies. Reciprocally, thorough consideration of the events leading to ectopic chondrocyte differentiation appears crucial to further increase our understanding of growth plate formation. In this context, we will review the effects of known or suspected factors that promote chondrogenic differentiation in growth plate and arteries. BioEssays 27:708–716, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Ne serait-ce que par son titre, dont l’oxymore est d’emblée assumée (p.11) et dont les protagonistes sont associés d’une manière qui ne laisse de surprendre, l’ouvrage de Julien Boudon publié dans la collection « Les sens du droit » des éditions Dalloz, mériterait de retenir l’attention.Dans ce court opus, l’auteur entend, à travers un examen qui puise tout à la fois aux sources de l’histoire, de la philosophie, du droit, de la science politique, et qui emprunte à la fois (...) au style de la monog.. (shrink)

Sven Rosenkranz’s Justification as Ignorance shows how a strongly internalist conception of justification can be derived from a strongly externalist conception of knowledge, given an identification of justification with second-order ignorance and a set of structural principles concerning knowing and being in a position to know. Among these principles is an epistemic analogue of the Geach modal schema which states that one is always in a position to know that one doesn’t know p or in a position to know that (...) one doesn’t know not-p. Even suitably refined, the principle faces a range of counterexamples in which it misleadingly and persistently seems to one that one knows whether p without it seeming to one that one knows p nor that one knows not-p. These cases also threaten the book’s case for the luminosity of second-order ignorance, which is in turn central to its derivation of strongly internalist principles of justification. (shrink)

Objective Our study sought to (1) describe the practices and preferences of Colombian adolescents in accessing sexual and reproductive health services: accompanied versus alone; (2) compare actual practices with stated preferences; and (3) determine age and gender differences regarding the practice and these stated preferences. -/- Methods 812 participants aged 11–24 years old answered a survey in two Profamilia clinics in the cities of Medellin and Cali in Colombia. A cross-sectional analysis was performed to compare participants’ answers based on the (...) variables of gender and age. -/- Results A quarter of participants visited the clinic alone (25.4%). Females were more likely to go alone in comparison to males (26.3% vs 14.1%; p = 0.031), and older participants went alone more often than younger participants (p < 0.001). Most participants – 72.7% (95 %CI: 69.3–75.9) – expressed a preference in being accompanied to the clinic, and more than 90% had their preferences met. The preferences of older participants were, however, less likely to be met than those of younger participants (p < 0.001), notably, because they predominantly wanted to be accompanied. -/- Conclusion Contemporary public health and bioethics literature advocates in favor of developing health services that better meet the preferences of adolescents. The present research highlights an apparent blind spot related to the role that others (e.g., parents, friends, partners) can or should play in accompanying adolescent patients when they access sexual and reproductive health services. Respecting adolescents’ preferences, and hence their autonomy, is not simply a matter of ensuring freedom from constraints (e.g., their right and ability to go alone). Rather, it should also consider the liberty to choose whether to be accompanied when accessing SHRS and by whom. (shrink)

It is sometimes held that rules of inference determine the meaning of the logical constants: the meaning of, say, conjunction is fully determined by either its introduction or its elimination rules, or both; similarly for the other connectives. In a recent paper, Panu Raatikainen (2008) argues that this view - call it logical inferentialism - is undermined by some "very little known" considerations by Carnap (1943) to the effect that "in a definite sense, it is not true that the standard (...) rules of inference" themselves suffice to "determine the meanings of [the] logical constants" (p. 2). In a nutshell, Carnap showed that the rules allow for non-normal interpretations of negation and disjunction. Raatikainen concludes that "no ordinary formalization of logic ... is sufficient to `fully formalize' all the essential properties of the logical constants" (ibid.). We suggest that this is a mistake. Pace Raatikainen, intuitionists like Dummett and Prawitz need not worry about Carnap's problem. And although bilateral solutions for classical inferentialists - as proposed by Timothy Smiley and Ian Rumfitt - seem inadequate, it is not excluded that classical inferentialists may be in a position to address the problem too. (shrink)

In their environment, plants are continuously submitted to natural stimuli such as wind, rain, temperature changes, wounding, etc. These signals induce a cascade of events which lead to metabolic and morphogenetic responses. In this paper the different steps are described and discussed starting from the reception of the signal by a plant organ to the final morphogenetic response. In our laboratory two plants are studied: Bryonia dioica for which rubbing the internode results in reduced elongation and enhanced radial expansion and (...) Bidens pilosa for which the response occurs at distance, hence pricking the cotyledon of a plantlet induces the growth inhibition of both the hypocotyl and the axillary bud of the pricked cotyledon. Reception of the signal and transmission of the message. In Bryonia the signal is received by epidermal cells while in Bidens they are the cells adjacent to the midrib of the cotyledon which receive the mechanical signal. In both plants the message is transmitted via a wave of electric depolarization. This latter is composed of an action potential associated with a slow wave whose transmission rates are respectively 1cm s−1 and 1 mm s−1. Recent results have shown the involvement of Ca2+ in the triggering of the slow wave and the role of the H+ pump during the slow wave. Transient and fast biochemical responses. An entry of extraceilular Ca2+ into the cells and a transient increase in IP3 occur within seconds following the mechanical stimulus. At the same time, the membrane becomes more fluid, correlated with qualitative changes in phospholipids. The rapid increase in the concentration of peroxidated lipids may be correlated with ethylene biosynthesis which is stimulated after rubbing. Other parameters such as cytoplasmic pH, relative water content, hydric potential, membrane potential and modifications of K+, Mg2+-ATPase and Ca2+-ATPase activities, play a key role in the early responses induced by the traumatisms. Irreversible-biochemical responses. The mechanical stimulus performed on a Bryonia internode induces an acceleration of: i) enzymatic activities related to the lignification, ii) esterification of phenolic acids in the cell wall. Consequently the lignification process is accelerated. Storage of the information. After being received by the target cells the information can be stored during several days before being expressed. At the level of cotyledonary bud, the first message, previously stored, can be expressed or not by a second treatment. Bidens thus behaves as if it was able to “store” and to “retrieve” morphogenetic messages, using a sort of rudimentary memory. The nuclei of the bud cells of the pricked cotyledon show that these cells, initially in G2 phase, divide and then remain in the G1 phase. In Bryonia, calli derived from young stimulated internodes, keep thigmomorphogenetic characteristics during several weeks. In the last part of this paper the particularity of our plant model which permits a study of the transmission and storage of the message, is underlined. The links between the different steps induced by the stimulus are discussed. Special attention is devoted to second messengers and to the amplification of the message. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Ackermann Guy, « Artémis et les enfants morts en bas âge. Une nouvelle statuette en bronze de l’Artémis d’Éphèse découverte à Érétrie », RA 74–2 (2022), p. 307–348 [tente d’éclairer les raisons du dépôt d’une statuette en bronze d’Artémis à côté d’ossements d’enfants décédés au moment de l’accouchement ou dans les jours suivants. L’hypothèse avancée est celle d’une offrande propitiatoire réalisée par des sages-femmes, qui auraient par ce geste placé leur activité sous la protection d’Artémis]...

Cet ouvrage collectif, qui rassemble onze contributions, est issu d’un colloque international organisé en 2012 et faisant suite à des ateliers de travail et des journées d’études, réalisés au sein du centre de recherche d’Anthropologie et d’Histoire des Mondes Anciens (AnHiMA). Le cadre de la réflexion est posé dès l’introduction par les deux responsables scientifiques de la publication, C. Calame et P. Ellinger. Les mythes grecs n’existent que dans la forme esthétique (poétique ou iconograph...

Ce volume, regroupant 13 contributions, publie les actes d’un colloque tenu en mai 2017 à l’université de Lausanne. Avec l’ambition, d’emblée énoncée par ses éditeurs, de « compare and contrast the development of royal and heroic cults in the Hellenistic period » (p. 1), le présent ouvrage vise à examiner les évolutions, transformations et mutations culturelles qu’ont connues les cultes et honneurs dévolus aux êtres humains dans le bassin méditerranéen, tout au long de l’époque hellénistique....

In their environment, plants are continuously submitted to natural stimuli such as wind, rain, temperature changes, wounding, etc. These signals induce a cascade of events which lead to metabolic and morphogenetic responses.In this paper the different steps are described and discussed starting from the reception of the signal by a plant organ to the final morphogenetic response. In our laboratory two plants are studied: Bryonia dioica for which rubbing the internode results in reduced elongation and enhanced radial expansion and Bidens (...) pilosa for which the response occurs at distance, hence pricking the cotyledon of a plantlet induces the growth inhibition of both the hypocotyl and the axillary bud of the pricked cotyledon. (shrink)

Prolongeant ses propres expertises, ainsi que les travaux de D. Mayaffre et D. Labbé & D. Monière, sur le discours politique de la Ve République, Le grand oral de P. Marchand, ambitionne de dégager, au moyen de méthodes issues des statistiques textuelles (et de l’analyse de contenu) – et sur un corpus exhaustif de déclarations de politique générale des Premiers ministres de la Ve République devant le parlement français (allant de Michel Debré le 8 janvier 1959 à Dominique de Villepin (...) le 16 ma.. (shrink)

Prolongeant ses propres expertises, ainsi que les travaux de D. Mayaffre et D. Labbé & D. Monière, sur le discours politique de la Ve République, Le grand oral de P. Marchand, ambitionne de dégager, au moyen de méthodes issues des statistiques textuelles (et de l’analyse de contenu) – et sur un corpus exhaustif de déclarations de politique générale des Premiers ministres de la Ve République devant le parlement français (allant de Michel Debré le 8 janvier 1959 à Dominique de Villepin (...) le 16 ma... (shrink)

This article is devoted to the analysis of the remarks of Gödel's Maxims and Philosophical remarks (Max Phil) that present a solution to the paradoxes of set theory, and to the analysis of the context. It is divided in two parts. The first part contains two remarks from the notebook IX, (pp. 48b, 51) on the question of the strategies for the solution of paradoxes. They clearly show Gödel’s preference for the strategy of limited ranges of significance. The reasons why (...) Gödel was also interested in the other strategies suggested by Russell is explained through two remarks of Max Phil IX (pp.69 and 72b) The second part presents a remark from Max Phil X (p. 28-29), and explains it from the perspective of Gödel analysis of concepts in the early 1943. (shrink)

We analyze the notions of indiscernibility and indeterminacy in the light of the Galois theory of field extensions and the generalization to \(K\) -algebras proposed by Grothendieck. Grothendieck’s reformulation of Galois theory permits to recast the Galois correspondence between symmetry groups and invariants as a Galois–Grothendieck duality between \(G\) -spaces and the minimal observable algebras that discern (or separate) their points. According to the natural epistemic interpretation of the original Galois theory, the possible \(K\) -indiscernibilities between the roots of a (...) polynomial \(p(x)\in K[x]\) result from the limitations of the field \(K\) . We discuss the relation between this epistemic interpretation of the Galois–Grothendieck duality and Leibniz’s principle of the identity of indiscernibles. We then use the conceptual framework provided by Klein’s Erlangen program to propose an alternative ontologic interpretation of this duality. The Galoisian symmetries are now interpreted in terms of the automorphisms of the symmetric geometric figures that can be placed in a background Klein geometry. According to this interpretation, the Galois–Grothendieck duality encodes the compatibility condition between geometric figures endowed with groups of automorphisms and the ‘observables’ that can be consistently evaluated at such figures. In this conceptual framework, the Galoisian symmetries do not encode the epistemic indiscernibility between individuals, but rather the intrinsic indeterminacy in the pointwise localization of the figures with respect to the background Klein geometry. (shrink)

The preparation of a supplement to Recueil des inscriptions en linéaire A. Observations on work in progress The work on a supplement to the Recueil des inscriptions en linéaire A by L. Godart and J.-P. Olivier, which will include the inscriptions published since 1985, allows presenting the characteristics of this corpus from a new angle. This article tries to define evolutions in the date, geography, and balance between different materials and types of inscriptions.

This new anthology of early modern philosophy enriches the possibilities for teaching this period by highlighting not only metaphysics and epistemology, but also new themes such as virtue, equality and difference, education, the passions, and love. It contains the works of forty-three philosophers, including traditionally taught figures such as Descartes, Spinoza, Leibniz, Locke, Berkeley, Hume, and Kant, as well as less familiar writers such as Lord Shaftesbury, Anton Amo, Julien Offray de La Mettrie, and Denis Diderot. It also highlights (...) the contributions of women philosophers, including Margaret Cavendish, Anne Conway, Gabrielle Suchon, Sor Juana Inéz de la Cruz, and Emilie Du Châtelet. (shrink)

Luddism constituted a phase in English social history between 1811 and 1817, a phase marked by a remarkably widespread phenomenon of machine-breaking. Ignored for generations, and subsequently the object of denigration, Luddism came in for a reevaluation in E. P. Thomson's book The Making of the English Working Class (1963), which fused a “Marxist” political perspective and the acutest requirements of historical scholarship. In subsequent research, these two perspectives have drifted apart. On the one hand, Thomson's historiographical heirs no longer (...) subscribe to their predecessor's militant stance. On the other, those researchers whose active commitment to the cause of political ecology since the 1990s had led them to inject urgency into the historiographical debate, have proved less convincing in terms of their contribution to historical scholarship. Luddism remains nevertheless a contemporary issue, both in historiography and in political philosophy. (shrink)

PurposeOlder adults aged 60 years and above are classified as being of high-risk for infection during the COVID-19 pandemic. This study aimed to investigate the associations of psychological factors of preventive behaviors with three preventive behaviors among Chinese older adults during the COVID-19 pandemic.MethodsA cross-sectional questionnaire survey was administered via SOJUMP, a widely used online survey platform in China. A total of 928 older adults were recruited using a snowball sampling approach from Hubei Province and outside Hubei Province in China (...) during May 18, 2020 to June 7, 2020. Multiple hierarchical regressions were conducted with four models to examine the association between demographic, past behavior, psychological factors and each preventive behavior.Principal FindingsAll three preventive behaviors in older adults increased dramatically during the pandemic of COVID-19. Gender, living status, educational level, past behavior, health knowledge, intention and planning significantly predicted hand washing behavior, R2 = 0.395, F = 54.372, p < 0.001. Gender, education level, important others infection, past behavior, health knowledge, planning and action control significantly predicted mask wearing behavior, R2 = 0.202, F = 23.197, p < 0.001. Living place, past behavior and health knowledge significantly predicted social distancing behavior, R2 = 0.204, F = 26.201, p < 0.001.Major ConclusionsPast behavior and health knowledge predicted all three preventive behaviors. Planning was an important psychological factor for both hand washing and mask wearing behaviors. All those critical demographic and psychological factors are critical for future interventions to facilitate older adults to comply with three preventive behaviors in daily life and to stay healthy during the COVID-19 pandemic. (shrink)

This collection’s basic theme and thesis, explained by Curtis L. Hancock, “A Critique of Social Construct Theory” and “A Counterfeit Choice,” is that the seeds of contemporary relativism were sown by modern philosophy, primarily Descartes himself, its founder. Following a lead from Gilson, these authors pursue the benefits of classical realism and existential Thomism compared with the Cartesian legacy of subjectivism in modern philosophy. Indeed, Peter Redpath, “Why Descartes was not a Philosopher,” explains why Descartes may not be a philosopher (...) at all, if the significance of the term be properly considered as a love of wisdom and a search for true being. As Maritain coined the phrase, he is an “ideosopher,” in pursuit of the effective idea and rhetorical success, not the contemplation of being. Christopher Cullen, “Transcendental Thomism: Realism Rejected,” argues that the attempt by Karl Rahner, Joseph Donceel, and others to absorb the Cartesian and Kantian approach into Thomism has not proved successful. Robert Geis, “Descartes’s Res: An Interactionist Difficulty,” explains how the objectifying of mind as a thing sets up insoluble difficulties; he argues that a more adequate account is found in Aristotle. Donald DeMarco, “Descartes, Mathematics and Music,” traces out the effect in music when the physical is reduced to the mathematical. The imposition of a uniform method leads to a distortion of what musicians do. William J. Fossati, “Maximum Influence from Minimum Abilities: La Mettrie and Radical Materialism,” traces the Cartesian heritage of reductionism through Julien Offroy de Le Mettrie to the most contemporary attempts to explain human beings as mere biological organisms. (shrink)

Voici une dition qui contribuera sans doute clairer une activit encore mal connue de Voltaire, celle d' diteur. Car de cette uvre composite qu'est le Discours de l'empereur Julien Voltaire se veut avant tout et reste bien l'organisateur, empruntant l'empereur du IVe si cle le r quisitoire qu'il a dress dans son Contre les Galil ens et au marquis d'Argens, son moderne et premier traducteur, la 'belle infid le' qu'il a donn e lire cinq ans plus t t ceux (...) qui n'entendaient ni le grec ni le latin. Voltaire n'a cependant conserv le joyau que pour le servir dans une monture toute nouvelle: d'Argens avait accompagn sa traduction d'une substantielle pr face et d'une annotation abondante; mais Voltaire a cart la premi re et retenu un tiers seulement de la seconde, encadrant d sormais le Discours de ses propres textes; en pr faces un 'Avis au lecteur' suivi d'un 'Portrait de l'empereur Julien' et d'un 'Examen du Discours'; en postface un virulent 'Suppl ment au Discours'. A quoi l'on ajoutera les quarante-quatre notes r dig es par l' diteur et qui s'adjoignent aux treize notes de d'Argens qu'il a conserv es; ce sont les 'nouvelles notes de divers auteurs' annonc s par la page de titre et dont quatre sont sign es Damilaville, Boulanger, Bolingbroke et 'le th ologien Th ro': sous ces noms d'emprunt, l' diteur ne s'est pas fait scrupule de r utiliser certains de ses textes ant rieurs, pas plus qu'il n'a craint, par de simples coupes habilement op r es dans certaines notes de d'Argens, de d figurer l'occasion la pens e du marquis quand elle se trouve contraire la sienne. Ainsi voit-on clairer sous ses diff rents aspects une activit ditoriale dont il fallait aussi p n trer les motifs. (shrink)

Taking our lead from Solomon’s emphasis on the importance of the intentional object of emotion, we review the history of repeated attempts to make this object disappear. We adduce evidence suggesting that in the case of James and Schachter, the intentional object got lost unintentionally. By contrast, modern constructivists seem quite determined to deny the centrality of the intentional object in accounting for the occurrence of emotions. Griffiths, however, downplays the role objects have in emotion noting that these do not (...) qualify as intentional. We argue that these disappearing acts, deliberate or not, generate fruitless debate and add little to the advancement of our understanding of emotion as an adaptive mechanism to cope with events that are relevant to an organism’s life. (shrink)

In this paper, we develop a fresh understanding of the sense in which emotions are evaluations. We argue that we should not follow mainstream accounts in locating the emotion–value connection at the level of content and that we should instead locate it at the level of attitudes or modes. We begin by explaining the contrast between content and attitude, a contrast in the light of which we review the leading contemporary accounts of the emotions. We next offer reasons to think (...) that these accounts face substantial problems since they locate the link emotions bear to values at the level of content. This provides the incentive to pursue an alternative approach according to which emotions qualify as evaluations because they are specific types of attitudes, an approach we substantiate by appealing to felt bodily stances. We conclude by considering two reasons why this approach may be resisted; they respectively pertain to the alleged impossibility of drawing the attitude–content contrast in the case of the emotions and to the suspicion that so doing raises qualia-related worries. (shrink)